3G Sonasource HIFU Focal Therapy Platform

Utilizing focused ultrasound, the Sonablate system is a minimally invasive robotic device that delivers precise and focused ablative energy.

Prostate Care Revolutionized
Sonablate is the first SonaSurgery probe to be commercialized. This unique image-guided device allows physicians to create a customized plan for each patient’s individual prostate needs.

Ultrasound energy, or sound waves, is transmitted through the rectal wall and focused at desired locations within the prostate identified by MRI and confirmed by ultrasound.

At the focal point of these sound waves, tissue temperature rapidly rises to almost 90 degrees Celsius (195 degrees Fahrenheit), destroying the targeted tissue while surrounding tissue remains unharmed. Sonablate features integrated imaging and ablation transducers that are controlled automatically allowing Sonablate to AIM, ABLATE, and ANALYZE the results of the ablation.


Minimally Invasive

Real-Time Imaging

Sonafuse (US / mpMRI Image Fusion

TCM (Tissue Change Monitoring

Sonablate is Powered by Unique A3 Technology:

1. AIM

Aim at specific tissue using ultrasound-MR fusion.


Ablate with pinpoint accuracy while sparing untargeted tissue.


Analyze using real-time imaging and advanced TCM Technology.

Key Product Features & Benefits


Sonafuse, the HIFU Fusion Platform, takes an open architecture approach to integrating Sonablate planning software with existing mpMRI fusion biopsy platforms in the market. Segmented and annotated DICOM radiology images are imported into Sonablate from your preferred fusion solution and fused with live ultrasound images to enable targeted HIFU planning

Planning Software using
MRI/US Fusion

Product Attributes:

  • Premier focal precision
  • Enhanced tissue targeting
  • Advanced image registration
  • Simple interface
  • Combines the rich detail of MRI with simple real-time US
  • Optimized HIFU ablation leveraging targeted Bx data
  • Premier focal precision
  • Premier focal precision
  • Premier focal precision

Tissue Change Monitoring (TCM)

TCM is a unique, quantitative software module that displays real-time changes occurring in prostate tissue ablated with HIFU. Rather than depicting changes in temperature, TCM assesses RF signal changes that may indicate tissue destruction.

How Does TCM Work?

A radio frequency (RF) signal is sent to a targeted ablation site prior to delivery of HIFU and then another signal is sent after delivery of HIFU to the same site.

TCM quantifies tissue changes based on a comparison of RF ultrasound pulse-echo signals at each ablation site. Easy-to-read on-screen color overlays and focal point markers are one of many indicators to guide HIFU delivery.


Sonalink is a remote viewing telecommunication application that is comes standard on every Sonablate system and is accessible by any facility that is in compliance with the terms of their purchase agreement.

Sonalink “links” the room and the device being used to deliver a case with remote support personnel. Two-way visual and auditory communication is provided between the physician and remote personnel, along with a Sonaplan screen mirroring app.

Sonalink allows the complete procedure, ranging from device setup to active computer-controlled HIFU delivery, to be remotely monitored by experienced support personnel. These specialists have the ability to interact with the physician and OR staff in real-time to answer questions and provide ongoing training and guidance in the use of the device.

TCM quantifies tissue changes based on a comparison of RF ultrasound pulse-echo signals at each ablation site. Easy-to-read on-screen color overlays and focal point markers are one of many indicators to guide HIFU delivery.

Sonablate Safety Features

Total Acoustic Power (TAP) Control

Total acoustic power, or TAP, is adjustable for each individual dose of HIFU, allowing power to be aligned with the varying specific characteristics over the entire volume of the gland.

Reflectivity Index Monitor (RIM)

RIM is used to assist the physician in monitoring energy deposition in the rectal wall. The RIM box measures the pixel brightness level of the image as seen in a defined rectangular region (RIM box) which is placed such that it encompasses the rectal wall in both the live and reference sagittal images

Software compares changes in the image in the RIM box between the treatment and reference images, displaying a numerical RIM value as the pixel brightness level within the yellow box changes. A rising RIM value suggests that the region within the box is accumulating potentially excess heat that could damage the rectal wall. Specified safety conditions cause the software to halt the treatment automatically.

Clinical Applications

Focal Gland Ablation

Hemi Gland Ablation

Whole Gland Ablation

Comprehensive Prostate Care Model

SONABLATE Published Studies

Diagnostic accuracy of multi-parametric MRI and TRUS biopsy in prostate cancer (PROMIS):
a paired validating confirmatory study

View Article

Focal Ablation Targeted to the Index Lesion in Multifocal Localised
Prostate Cancer:
a Prospective Development Study

View Article

Phase I/II Trial of High Intensity Focused Ultrasound
for the Treatment of Previously Untreated Localized Prostate Cancer

View Article

High-intensity focused ultrasound for the treatment of prostate cancer:
A prospective trial with long-term follow-up

View Article

Improved Outcomes with Advancements
in High Intensity Focused Ultrasound Devices for the Treatment of Localized Prostate Cancer

View Article

Twelve Years' Experience with High-Intensity Focused Ultrasound (HIFU)
using Sonablate Devices for the treatment of Localized Prostrate Cancer

View Article

Focal High-intensity Focused Ultrasound Targeted Hemiablation for Unilateral Prostate Cancer:
A Prospective Evaluation of Oncologic and Functional Outcomes

View Article

Whole-Gland Salvage High-Intensity Focused Ultrasound Therapy
for Localized Prostate Cancer Recurrence After External Beam Radiation Therapy

View Article

The Effects of Focal Therapy for Prostate Cancer on Sexual Function:
A Combined Analysis of Three Prospective Trials

View Article

New and Established Technology in Focal Ablation of the Prostate:
A Systematic Review

View Article

Focal therapy for localised unifocal and multifocal prostate cancer:
a prospective development study

View Article

Focal Salvage Therapy:
for Localized Prostate Cancer Recurrence After External Beam Radiotherapy

View Article


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